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Main Page
What is HIV?
Where did HIV come from?
What is MHC and what does it do?
What is the molecular basis of
chimpanzee resistance to SIVcpz?
Are there allelic variants in human population that
are protective against HIV?
How are humans adapting to
selection pressures produced by HIV? What will the future bring?
References
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Check, E. (2006).
“Staying the course.” Nature, 442, 617-619.
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de Groot et al. (2002).
“ Evidence for an ancient selective sweep in the MHC class I gene
repertoire of chimpanzees.” PNAS 99(18),
11748-11753
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Heeney et al. (2006).
“Origins of HIV and the Evolution of Resistance to AIDS.”
Science, 313,
462-466.
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Kleplela et al. (2004).
“ Dominant influence of HLA-B in mediating the potential co-evolution of
HIV and HLA.” Nature, 432, 769-774.
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McMicheal, A & Klenerman, P. (2002). “
HLA leaves its footprints on HIV.”
Science, 296,
1410-1411.
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Nolan, D., James, I. & Mallal, S. (2005). “
HIV: Experiencing the pressures of modern life.” Science,
307, 1422-1444
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O’Brien, S. & Nelson, G. (2004).
“Human genes that limit AIDS.” Nature
Genetics, 36(6),
565-574.
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Rambaut et al. (2004).
“ The causes and evolutionary consequences of HIV evolution.”
Nature Reviews Genetics, 5, 52-61.
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Sharp, P., Shaw, G. & Hahn, B. (2005).
“Simian immunodeficiency virus infection in chimpanzees.” Journal
of Virology, 79(7),3891-3902
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Balla-Jhagjhoorsingh et al. (2003).
“Specific nature of cellular immune responses elicited by chimpanzees
against HIV-1.” Human Immunology, 64, 681-689.
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Trachtenberg et al. (2003).
"Advantage of rare HLA supertype in HIV disease progression."
Nature Medicine, 9 (7), 928-935.
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Wooding et al. (2005).
“Contrasting effects of
natural selection on human and chimpanzee CC ckemokine receptor 5.”
American Journal of Human Genetics, 76,291-301
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